We’re interested in understanding how S. aureus subverts macrophage function (particularly through regulation of toxin release by 2 component systems) and how the host innate immune system responds to infection.
Our work combines whole genome sequencing of both bacteria and host, forward and reverse genetic screening, advanced light microscopic techniques, and cellular and whole animal infection models to understand the molecular basis of bacteria-host interactions.
Innate Immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus.
Hepburn L, et al.,Science. 2014 Oct 31;346(6209):641-6.