Major Publications
2019
Same meat, different gravy: ignore the new names of mycobacteria.
Tortoli E, [...], Floto RA, et al.
Eur Respir J. 2019 Jul 11;54(1). pii: 1900795. doi: 10.1183/13993003.00795-2019.
PMID:31296783
Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
Whitehouse AJ, Thomas SE, Brown KP*, Fanourakis A, Chan DS, Libardo MDJ, Mendes V, Boshoff HIM, Floto RA, Abell C, Blundell TL, Coyne AG.
J Med Chem. 2019 Aug 8;62(15):7210-7232. doi: 10.1021/acs.jmedchem.9b00809.
PMID:31282680
Germline selection shapes human mitochondrial DNA diversity.
Wei W, [...], Floto RA, [...], Chinnery PF.
Science. 2019 May 24;364(6442). pii: eaau6520. doi: 10.1126/science.aau6520.
PMID:31123110
Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation.
Segovia M, [...], Floto RA, [...], Hill M.
Cancer Cell. 2019 May 13;35(5):767-781.e6. doi: 10.1016/j.ccell.2019.04.003.
PMID:31085177
Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping.
Thomas SE, [...], Floto RA, von Delft F, Blundell TL.
Philos Trans A Math Phys Eng Sci. 2019 Jun 17;377(2147):20180422. doi: 10.1098/rsta.2018.0422.
PMID:31030650
Pathophysiology, causes and genetics of paediatric and adult bronchiectasis.
Bush A, Floto RA.
Respirology. 2019 Feb 25. doi: 10.1111/resp.13509. [Epub ahead of print] Review.
PMID:30801930
CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses.
Bernut A, Dupont C, Ogryzko NV, Neyret A, Herrmann JL, Floto RA, Renshaw SA, Kremer L.
Cell Rep. 2019 Feb 12;26(7):1828-1840.e4. doi: 10.1016/j.celrep.2019.01.071.
PMID:30759393
British Thoracic Society Guideline for bronchiectasis in adults.
Hill AT, Sullivan AL, Chalmers JD, De Soyza A, Elborn SJ, Floto AR, et al.
Thorax. 2019 Jan;74(Suppl 1):1-69. doi: 10.1136/thoraxjnl-2018-212463. No abstract available.
PMID:30545985
Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research.
Daniel-Wayman S, [...], Floto RA, et al.
Am J Respir Crit Care Med. 2019 Apr 15;199(8):947-951. doi: 10.1164/rccm.201807-1273PP. No abstract available.
PMID:30428263
Multi-centre ethics and research governance review can impede non-interventional clinical research.
Duplancic C, Crough T, Bell SC; Australian Non-tuberculous Mycobacteria in Cystic Fibrosis Study Group.
Intern Med J. 2019 Jun;49(6):722-728. doi: 10.1111/imj.14158.
PMID:30417974
2018
British Thoracic Society guideline for bronchiectasis in adults.
Hill AT, Sullivan AL, Chalmers JD, De Soyza A, Elborn JS, Floto RA, et al.
BMJ Open Respir Res. 2018 Dec 28;5(1):e000348. doi: 10.1136/bmjresp-2018-000348.
PMID:30687502
Monocyte Function in Parkinson's Disease and the Impact of Autologous Serum on Phagocytosis.
Wijeyekoon RS, Kronenberg-Versteeg D, Scott KM, Hayat S, Jones JL, Clatworthy MR, Floto RA, Barker RA, Williams-Gray CH.
Front Neurol. 2018 Oct 16;9:870. doi: 10.3389/fneur.2018.00870. eCollection 2018.
PMID:30386290
Mutations in the MAB_2299c TetR Regulator Confer Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus.
Richard M, Gutiérrez AV, Viljoen A, Rodriguez-Rincon D*, Roquet-Baneres F, Blaise M, Everall I*, Parkhill J, Floto RA, Kremer L.
Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01316-18. doi: 10.1128/AAC.01316-18.
PMID:30323043
Latent class analysis to define radiological subgroups in pulmonary nontuberculous mycobacterial disease.
Cowman SA, Jacob J, Obaidee S, Andres Floto R, Wilson R, Haworth CS, Loebinger MR.
BMC Pulm Med. 2018 Aug 31;18(1):145. doi: 10.1186/s12890-018-0675-8.
PMID:30170572
2017
British Thoracic Society Guideline for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD).
Haworth CS, [...], Floto RA.
BMJ Open Respir Res. 2017 Oct 19;4(1):e000242. doi: 10.1136/bmjresp-2017-000242.
PMID:29449949
Introducing the new BTS Guideline: Management of non-tuberculous mycobacterial pulmonary disease (NTM-PD).
Haworth CS, Floto RA.
Thorax. 2017 Nov;72(11):969-970. doi: 10.1136/thoraxjnl-2017-210929.
PMID:29054887
British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD).
Haworth CS, [...], Floto RA.
Thorax. 2017 Nov;72(Suppl 2):ii1-ii64. doi: 10.1136/thoraxjnl-2017-210927.
PMID:29054853
***Genomic epidemiology of a national outbreak of post-surgical Mycobacterium abscessus wound infections in Brazil.
Everall I, [...], Floto RA, Parkhill J, Leão SC, Harris SR.
Microb Genom. 2017 May 3;3(5):e000111.
Examining the Effect of Residual Amikacin on Sputum Culture for Nontuberculous Mycobacteria.
Eagle G, Brown K, Floto RA.
Am J Respir Crit Care Med. 2017 Jun 23. doi: 10.1164/rccm.201704-0792LE.
Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection.
Péan CB, [...], Andres Floto R, Dionne MS.
Nat Commun. 2017 Mar 6;8:14642.
Poor adherence to management guidelines in nontuberculous mycobacterial pulmonary diseases.
van Ingen J,[..], Floto RA, et al..
Eur Respir J. 2017 Feb 15;49(2).
PMID: 28182571
2016
***Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.
Bryant JM*, Grogono DM*,[...], Floto RA.
Science. 2016 : 751-757.
C13orf31 (FAMIN) is a central regulator of immunometabolic function.
Cader MZ, [...], Floto RA, et al.,.
Nat Immunol. 2016 Aug 1. doi: 10.1038/ni.3532.
Epidemiology of nontuberculous mycobacteria (NTM) amongst individuals with cystic fibrosis (CF).
Viviani L, Harrison MJ, Zolin A, Haworth CS, Floto RA.
J Cyst Fibros. 2016 Mar 31.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ,[...], Floto RA, et al.,.
Autophagy. 2016 Jan 2;12(1):1-222.
US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis: executive summary.
Floto RA, et al.,.
Thorax. 2016 Jan;71(1):88-90. doi: 10.1136/thoraxjnl-2015-207983.
US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis.
Floto RA, et al.,.
Thorax. 2016 Jan;71 Suppl 1:i1-i22. doi: 10.1136/thoraxjnl-2015-207360.
2015
Mycobacterium abscessus Complex Identification with Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry.
Panagea T, [...], Floto RA, Gilligan P.
J Clin Microbiol. 2015 Jul;53(7):2355-8. doi: 10.1128/JCM.00494-15.
Emerging bacterial pathogens and changing concepts of bacterial pathogenesis in cystic fibrosis.
Parkins MD, Floto RA.
J Cyst Fibros. 2015 May;14(3):293-304. doi: 10.1016/j.jcf.2015.03.012.
Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
Lourenco S, [...], Floto RA, Janes SM.
J Immunol. 2015 Apr 1;194(7):3463-74. doi: 10.4049/jimmunol.1402097.
The growing threat of nontuberculous mycobacteria in CF.
Floto RA, Haworth CS.
J Cyst Fibros. 2015 Jan;14(1):1-2. doi: 10.1016/j.jcf.2014.12.002.
2014
*** Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion.
Schiebler M, [...], Floto RA.
EMBO Mol Med. 2014 Dec 22;7(2):127-39. doi: 10.15252/emmm.201404137.
*** Innate Immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus.
Hepburn L, [...], Floto RA.
Science. 2014 Oct 31;346(6209):641-6. doi: 10.1126/science.1258705.
Autologous dendritic cells prolong allograft survival through Tmem176b-dependent antigen cross-presentation.
Segovia M, [...] Floto RA, et al.,.
Am J Transplant. 2014 May;14(5):1021-31. doi: 10.1111/ajt.12708.
Human urinary exosomes as innate immune effectors.
Hiemstra TF, [...], Floto RA et al.,.
J Am Soc Nephrol. 2014 Sep;25(9):2017-27. doi: 10.1681/ASN.2013101066.
2013
*** Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study.
Bryant JM, [...], Floto RA.
Lancet. 2013 May 4;381(9877):1551-60. doi: 10.1016/S0140-6736(13)60632-7.
Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.
Mueller M, [...], Floto RA, et al.,.
Am J Hum Genet. 2013 Jan 10;92(1):28-40. doi: 10.1016/j.ajhg.2012.11.013.
2012
Treatment of Mycobacterium abscessus: all macrolides are equal, but perhaps some are more equal than others.
Stout JE, Floto RA.
Am J Respir Crit Care Med. 2012 Nov 1;186(9):822-3. doi: 10.1164/rccm.201208-1500ED.
Non-tuberculous mycobacteria in cystic fibrosis.
Hill UG, Floto RA, Haworth CS.
J R Soc Med. 2012 Jun;105 Suppl 2:S14-8. doi: 10.1258/jrsm.2012.12s003.
Constitutive expression of a Mg2+-inhibited K+ current and a TRPM7-like current in human erythroleukemia cells.
Mason MJ, Schaffner C, Floto RA, Teo QA.
Am J Physiol Cell Physiol. 2012 Mar 15;302(6):C853-67. doi: 10.1152/ajpcell.00071.2011.
2011
*** Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection.
Renna M, [...], Floto RA.
J Clin Invest. 2011 Sep;121(9):3554-63. doi: 10.1172/JCI46095.
Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex.
Renna M, Schaffner C, Winslow AR, Menzies FM, Peden AA, Floto RA, Rubinsztein DC.
J Cell Sci. 2011 Feb 1;124(Pt 3):469-82. doi: 10.1242/jcs.076489.
2009
Differential signal transduction, membrane trafficking, and immune effector functions mediated by FcgammaRI versus FcgammaRIIa.
Dai X, [...], Floto RA, et al.,.
Blood. 2009 Jul 9;114(2):318-27. doi: 10.1182/blood-2008-10-184457.
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.
Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC.
Cell Death Differ. 2009 Jan;16(1):46-56. doi: 10.1038/cdd.2008.110.
2008
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
Williams A, [...], Floto RA, Rubinsztein DC.
Nat Chem Biol. 2008 May;4(5):295-305. doi: 10.1038/nchembio.79.
Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb.
Brownlie RJ, [...], Floto RA, et al.,.
J Exp Med. 2008 Apr 14;205(4):883-95. doi: 10.1084/jem.20072565.
2007
*** Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages.
Floto RA, Sarkar S, Perlstein EO, Kampmann B, Schreiber SL, Rubinsztein DC.
Autophagy. 2007 Nov-Dec;3(6):620-2.
IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37.
Martineau AR, [...], Floto RA, et al.,.
J Immunol. 2007 Jun 1;178(11):7190-8.
Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.
Clatworthy MR, [...], Floto RA, Smith KG.
Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7169-74.
2006
*** Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5.
Floto RA, [...], Smith KG, Lehner PJ.
Science. 2006 Oct 20;314(5798):454-8.
2005
Lithium induces autophagy by inhibiting inositol monophosphatase.
Sarkar S, Floto RA, et al.,.
J Cell Biol. 2005 Sep 26;170(7):1101-11.
Loss of function of a lupus-associated FcgammaRIIb polymorphism through exclusion from lipid rafts.
Floto RA, et al.,.
Nat Med. 2005 Oct;11(10):1056-8.
2004
HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation.
MacAry PA, Javid B, Floto RA, Smith KG, Oehlmann W, Singh M, Lehner PJ.
Immunity. 2004 Jan;20(1):95-106.
2003
The vagus nerve, macrophages, and nicotine.
Floto RA, Smith KG.
Lancet. 2003 Mar 29;361(9363):1069-70.