Andres Floto Lab Cambridge University

Major Publications

2021

*** Stepwise pathogenic evolution of Mycobacterium abscessus.

Bryant JM, Brown KP, Burbaud S, Everall I, Belardinelli JM, Rodriguez-Rincon D, Grogono DM, Peterson CM, Verma D, Evans IE, Ruis C, Weimann A, Arora D, Malhotra S, Bannerman B, Passemar C, Templeton K, MacGregor G, Jiwa K, Fisher AJ, Blundell TL, Ordway DJ, Jackson M, Parkhill J, Floto RA.

Science. 2021 Apr 30;372(6541):eabb8699. doi: 10.1126/science.abb8699.

PMID: 33926925

The Impact of Hospital-Ward Ventilation on Airborne-Pathogen Exposure.

Mingotti N, Grogono D, [...], Floto RA, Woods AW.

Am J Respir Crit Care Med. 2021 Mar 15;203(6):766-769. doi: 10.1164/rccm.202009-3634LE.

PMID: 33211973

A multicentre analysis of Clostridium difficile in persons with Cystic Fibrosis demonstrates that carriage may be transient and highly variable with respect to strain and level.

Deane J, [...], Floto A, Rea MC, Ross RP, Stanton C, Plant BJ.

J Infect. 2021 Mar;82(3):363-370. doi: 10.1016/j.jinf.2020.12.027.

PMID: 33444699

2020

How artificial intelligence and machine learning can help healthcare systems respond to COVID-19.

van der Schaar M, Alaa AM, Floto A, Gimson A, Scholtes S, Wood A, McKinney E, Jarrett D, Lio P, Ercole A.

Mach Learn. 2020 Dec 9:1-14. doi: 10.1007/s10994-020-05928-x.

PMID: 33318723

Epidemiology of nontuberculous mycobacterial pulmonary disease in Europe and Japan by Delphi estimation.

Schildkraut JA, [...], Floto RA, Hoefsloot W, Griffith DE, Wagner D, Ingen JV

NTM-NET.Respir Med. 2020 Nov;173:106164. doi: 10.1016/j.rmed.2020.106164.

PMID: 32992265

Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation.

Bernut A, Loynes CA, Floto RA, Renshaw SA.

Front Immunol. 2020 Jul 31;11:1733. doi: 10.3389/fimmu.2020.01733. eCollection 2020.

PMID: 32849617

Producing polished prokaryotic pangenomes with the Panaroo pipeline.

Tonkin-Hill G, [...], Floto RA, Frost SDW, Corander J, Bentley SD, Parkhill J.

Genome Biol. 2020 Jul 22;21(1):180. doi: 10.1186/s13059-020-02090-4.

PMID: 32698896

Cell Surface Remodeling of Mycobacterium abscessus under Cystic Fibrosis Airway Growth Conditions.

Wiersma CJ, [...], Floto RA, Parkhill J, Ordway DJ, Davidson RM, McNeil MR, Jackson M.

ACS Infect Dis. 2020 Aug 14;6(8):2143-2154. doi: 10.1021/acsinfecdis.0c00214.

PMID: 32551551

How can airborne transmission of COVID-19 indoors be minimised?

Morawska L, Floto A, et al.

Environ Int. 2020 Sep;142:105832. doi: 10.1016/j.envint.2020.105832.

PMID: 32521345

Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease.

Wijeyekoon RS, [...], Floto RA, Barker RA, Williams-Gray CH.

Brain Behav Immun. 2020 Jul;87:473-488. doi: 10.1016/j.bbi.2020.01.018. Epub 2020 Jan 30.

PMID: 32006615

2019

***Polymeric nanobiotics as a novel treatment for mycobacterial infections.

Batalha IL, Bernut A, Schiebler M, Ouberai MM, Passemar C, Klapholz C, Kinna S, Michel S, Sader K, Castro-Hartmann P, Renshaw SA, Welland ME, Floto RA.

J Control Release. 2019 Nov 28;314:116-124. doi: 10.1016/j.jconrel.2019.10.009. Epub 2019 Oct 21.

PMID: 31647980

Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to Streptococcus pneumoniae.

Periselneris J, [...] Floto RA, Noursadeghi M, Brown JS.

mBio. 2019 Sep 24;10(5):e02144-19. doi: 10.1128/mBio.02144-19.

PMID: 31551336

Same meat, different gravy: ignore the new names of mycobacteria.

Tortoli E, [...], Floto RA, et al.

Eur Respir J. 2019 Jul 11;54(1). pii: 1900795. doi: 10.1183/13993003.00795-2019.

PMID:31296783

Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.

Whitehouse AJ, Thomas SE, Brown KP*, Fanourakis A, Chan DS, Libardo MDJ, Mendes V, Boshoff HIM, Floto RA, Abell C, Blundell TL, Coyne AG.

J Med Chem. 2019 Aug 8;62(15):7210-7232. doi: 10.1021/acs.jmedchem.9b00809.

PMID:31282680

Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping.

Thomas SE, [...], Floto RA, von Delft F, Blundell TL.

Philos Trans A Math Phys Eng Sci. 2019 Jun 17;377(2147):20180422. doi: 10.1098/rsta.2018.0422.

PMID:31030650

Multi-centre ethics and research governance review can impede non-interventional clinical research.

Duplancic C, Crough T, Bell SC; Australian Non-tuberculous Mycobacteria in Cystic Fibrosis Study Group.

Intern Med J. 2019 Jun;49(6):722-728. doi: 10.1111/imj.14158.

PMID:30417974

Germline selection shapes human mitochondrial DNA diversity.

Wei W, [...], Floto RA, [...], Chinnery PF.

Science. 2019 May 24;364(6442). pii: eaau6520. doi: 10.1126/science.aau6520.

PMID:31123110

Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation.

Segovia M, [...], Floto RA, [...], Hill M.

Cancer Cell. 2019 May 13;35(5):767-781.e6. doi: 10.1016/j.ccell.2019.04.003.

PMID:31085177

Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research.

Daniel-Wayman S, [...], Floto RA, et al.

Am J Respir Crit Care Med. 2019 Apr 15;199(8):947-951. doi: 10.1164/rccm.201807-1273PP. No abstract available.

PMID:30428263

Pathophysiology, causes and genetics of paediatric and adult bronchiectasis.

Bush A, Floto RA.

Respirology. 2019 Feb 25. doi: 10.1111/resp.13509. [Epub ahead of print] Review.

PMID:30801930

CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses.

Bernut A, Dupont C, Ogryzko NV, Neyret A, Herrmann JL, Floto RA, Renshaw SA, Kremer L.

Cell Rep. 2019 Feb 12;26(7):1828-1840.e4. doi: 10.1016/j.celrep.2019.01.071.

PMID:30759393

Mabellini: a genome-wide database for understanding the structural proteome and evaluating prospective antimicrobial targets of the emerging pathogen Mycobacterium abscessus.

Skwark MJ, Torres PHM, Copoiu L, Bannerman B, Floto RA, Blundell TL.

Database (Oxford). 2019 Jan 1;2019(1):baz113. doi: 10.1093/database/baz113.

PMID: 31681953

British Thoracic Society Guideline for bronchiectasis in adults.

Hill AT, Sullivan AL, Chalmers JD, De Soyza A, Elborn SJ, Floto AR, et al.

Thorax. 2019 Jan;74(Suppl 1):1-69. doi: 10.1136/thoraxjnl-2018-212463. No abstract available.

PMID:30545985

2018

British Thoracic Society guideline for bronchiectasis in adults.

Hill AT, Sullivan AL, Chalmers JD, De Soyza A, Elborn JS, Floto RA, et al.

BMJ Open Respir Res. 2018 Dec 28;5(1):e000348. doi: 10.1136/bmjresp-2018-000348.

PMID:30687502

Monocyte Function in Parkinson's Disease and the Impact of Autologous Serum on Phagocytosis.

Wijeyekoon RS, Kronenberg-Versteeg D, Scott KM, Hayat S, Jones JL, Clatworthy MR, Floto RA, Barker RA, Williams-Gray CH.

Front Neurol. 2018 Oct 16;9:870. doi: 10.3389/fneur.2018.00870. eCollection 2018.

PMID:30386290

Mutations in the MAB_2299c TetR Regulator Confer Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus.

Richard M, Gutiérrez AV, Viljoen A, Rodriguez-Rincon D*, Roquet-Baneres F, Blaise M, Everall I*, Parkhill J, Floto RA, Kremer L.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01316-18. doi: 10.1128/AAC.01316-18.

PMID:30323043

Latent class analysis to define radiological subgroups in pulmonary nontuberculous mycobacterial disease.

Cowman SA, Jacob J, Obaidee S, Andres Floto R, Wilson R, Haworth CS, Loebinger MR.

BMC Pulm Med. 2018 Aug 31;18(1):145. doi: 10.1186/s12890-018-0675-8.

PMID:30170572

2017

British Thoracic Society Guideline for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD).

Haworth CS, [...], Floto RA.

BMJ Open Respir Res. 2017 Oct 19;4(1):e000242. doi: 10.1136/bmjresp-2017-000242.

PMID:29449949

Introducing the new BTS Guideline: Management of non-tuberculous mycobacterial pulmonary disease (NTM-PD).

Haworth CS, Floto RA.

Thorax. 2017 Nov;72(11):969-970. doi: 10.1136/thoraxjnl-2017-210929.

PMID:29054887

British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD).

Haworth CS, [...], Floto RA.

Thorax. 2017 Nov;72(Suppl 2):ii1-ii64. doi: 10.1136/thoraxjnl-2017-210927.

PMID:29054853

***Genomic epidemiology of a national outbreak of post-surgical Mycobacterium abscessus wound infections in Brazil.

Everall I, [...], Floto RA, Parkhill J, Leão SC, Harris SR.

Microb Genom. 2017 May 3;3(5):e000111.

PMID:28884021

Examining the Effect of Residual Amikacin on Sputum Culture for Nontuberculous Mycobacteria.

Eagle G, Brown K, Floto RA.

Am J Respir Crit Care Med. 2017 Jun 23. doi: 10.1164/rccm.201704-0792LE.

PMID: 28644036

Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection.

Péan CB, [...], Andres Floto R, Dionne MS.

Nat Commun. 2017 Mar 6;8:14642.

PMID: 28262681

Poor adherence to management guidelines in nontuberculous mycobacterial pulmonary diseases.

van Ingen J,[..], Floto RA, et al..

Eur Respir J. 2017 Feb 15;49(2).

PMID: 28182571

2016

***Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.

Bryant JM*, Grogono DM*,[...], Floto RA.

Science. 2016 : 751-757.

PMID:27846606

C13orf31 (FAMIN) is a central regulator of immunometabolic function.

Cader MZ, [...], Floto RA, et al.,.

Nat Immunol. 2016 Aug 1. doi: 10.1038/ni.3532.

PMID: 27478939

Epidemiology of nontuberculous mycobacteria (NTM) amongst individuals with cystic fibrosis (CF).

Viviani L, Harrison MJ, Zolin A, Haworth CS, Floto RA.

J Cyst Fibros. 2016 Mar 31.

PMID: 27050794

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ,[...], Floto RA, et al.,.

Autophagy. 2016 Jan 2;12(1):1-222.

PMID: 26799652

US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis: executive summary.

Floto RA, et al.,.

Thorax. 2016 Jan;71(1):88-90. doi: 10.1136/thoraxjnl-2015-207983.

PMID: 26678435

US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis.

Floto RA, et al.,.

Thorax. 2016 Jan;71 Suppl 1:i1-i22. doi: 10.1136/thoraxjnl-2015-207360.

PMID: 26666259

2015

Mycobacterium abscessus Complex Identification with Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry.

Panagea T, [...], Floto RA, Gilligan P.

J Clin Microbiol. 2015 Jul;53(7):2355-8. doi: 10.1128/JCM.00494-15.

PMID: 25948607

Emerging bacterial pathogens and changing concepts of bacterial pathogenesis in cystic fibrosis.

Parkins MD, Floto RA.

J Cyst Fibros. 2015 May;14(3):293-304. doi: 10.1016/j.jcf.2015.03.012.

PMID: 25881770 Send request

Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.

Lourenco S, [...], Floto RA, Janes SM.

J Immunol. 2015 Apr 1;194(7):3463-74. doi: 10.4049/jimmunol.1402097.

PMID: 25712213

The growing threat of nontuberculous mycobacteria in CF.

Floto RA, Haworth CS.

J Cyst Fibros. 2015 Jan;14(1):1-2. doi: 10.1016/j.jcf.2014.12.002.

PMID: 25487786 Send request

2014

*** Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion.

Schiebler M, [...], Floto RA.

EMBO Mol Med. 2014 Dec 22;7(2):127-39. doi: 10.15252/emmm.201404137.

PMID: 25535254

*** Innate Immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus.

Hepburn L, [...], Floto RA.

Science. 2014 Oct 31;346(6209):641-6. doi: 10.1126/science.1258705.

PMID: 25359976

Autologous dendritic cells prolong allograft survival through Tmem176b-dependent antigen cross-presentation.

Segovia M, [...] Floto RA, et al.,.

Am J Transplant. 2014 May;14(5):1021-31. doi: 10.1111/ajt.12708.

PMID: 24731243

Human urinary exosomes as innate immune effectors.

Hiemstra TF, [...], Floto RA et al.,.

J Am Soc Nephrol. 2014 Sep;25(9):2017-27. doi: 10.1681/ASN.2013101066.

PMID: 24700864

2013

*** Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study.

Bryant JM, [...], Floto RA.

Lancet. 2013 May 4;381(9877):1551-60. doi: 10.1016/S0140-6736(13)60632-7.

PMID: 23541540

Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.

Mueller M, [...], Floto RA, et al.,.

Am J Hum Genet. 2013 Jan 10;92(1):28-40. doi: 10.1016/j.ajhg.2012.11.013.

PMID: 23261299

2012

Treatment of Mycobacterium abscessus: all macrolides are equal, but perhaps some are more equal than others.

Stout JE, Floto RA.

Am J Respir Crit Care Med. 2012 Nov 1;186(9):822-3. doi: 10.1164/rccm.201208-1500ED.

PMID: 23118083

Non-tuberculous mycobacteria in cystic fibrosis.

Hill UG, Floto RA, Haworth CS.

J R Soc Med. 2012 Jun;105 Suppl 2:S14-8. doi: 10.1258/jrsm.2012.12s003.

PMID: 22688361

Constitutive expression of a Mg2+-inhibited K+ current and a TRPM7-like current in human erythroleukemia cells.

Mason MJ, Schaffner C, Floto RA, Teo QA.

Am J Physiol Cell Physiol. 2012 Mar 15;302(6):C853-67. doi: 10.1152/ajpcell.00071.2011.

PMID: 22135214

2011

*** Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection.

Renna M, [...], Floto RA.

J Clin Invest. 2011 Sep;121(9):3554-63. doi: 10.1172/JCI46095.

PMID: 21804191

Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex.

Renna M, Schaffner C, Winslow AR, Menzies FM, Peden AA, Floto RA, Rubinsztein DC.

J Cell Sci. 2011 Feb 1;124(Pt 3):469-82. doi: 10.1242/jcs.076489.

PMID: 21242315

2009

Differential signal transduction, membrane trafficking, and immune effector functions mediated by FcgammaRI versus FcgammaRIIa.

Dai X, [...], Floto RA, et al.,.

Blood. 2009 Jul 9;114(2):318-27. doi: 10.1182/blood-2008-10-184457.

PMID: 19420354

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.

Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC.

Cell Death Differ. 2009 Jan;16(1):46-56. doi: 10.1038/cdd.2008.110.

PMID: 18636076

2008

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

Williams A, [...], Floto RA, Rubinsztein DC.

Nat Chem Biol. 2008 May;4(5):295-305. doi: 10.1038/nchembio.79.

PMID: 18391949

Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb.

Brownlie RJ, [...], Floto RA, et al.,.

J Exp Med. 2008 Apr 14;205(4):883-95. doi: 10.1084/jem.20072565.

PMID:18362174

2007

*** Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages.

Floto RA, Sarkar S, Perlstein EO, Kampmann B, Schreiber SL, Rubinsztein DC.

Autophagy. 2007 Nov-Dec;3(6):620-2.

PMID: 17786022 Send request

IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37.

Martineau AR, [...], Floto RA, et al.,.

J Immunol. 2007 Jun 1;178(11):7190-8.

PMID: 17513768

Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.

Clatworthy MR, [...], Floto RA, Smith KG.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7169-74.

PMID: 17435165

2006