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© 2019  Floto Group

Non-Tuberculous Mycobacteria

We are focused on understanding the biology and pathophysiology of infection with the rapid growing multidrug resistant NTM Mycobacterium abscessus as part of the Cystic Fibrosis Trust Strategic Research Centre; an international collaboration with Professor Sir Tom Blundell (Biochemistry, Cambridge), Prof. Julian Parkhill (WT Sanger Institute), Drs Diane Ordway and Mary Jackson (Colorado State University). Together we combine population-level whole genome sequencing, cell biology, biochemistry, animal modelling, structural biology, and computational biology to reveal virulence mechanisms, define host defence factors, and develop novel antibiotics.

Related publications:

Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.

Bryant JM*, Grogono DM*,[...], Floto RA.

Science. 2016 : 751-757. 

Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study.

Bryant JM et al., Lancet. 2013 May 4;381(9877):1551-60. 

PMID: 23541540

Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection.

Renna M et al., J Clin Invest. 2011 Sep;121(9):3554-63.

PMID: 21804191

Phylogenetic tree
Phylogenetic tree of M abscessus isolates indicates different modes of likely transmission