We are focused on understanding the biology and pathophysiology of infection with the rapid growing multidrug resistant NTM Mycobacterium abscessus as part of the Cystic Fibrosis Trust Strategic Research Centre; an international collaboration with Professor Sir Tom Blundell (Biochemistry, Cambridge), Prof. Julian Parkhill (WT Sanger Institute), Drs Diane Ordway and Mary Jackson (Colorado State University). Together we combine population-level whole genome sequencing, cell biology, biochemistry, animal modelling, structural biology, and computational biology to reveal virulence mechanisms, define host defence factors, and develop novel antibiotics.
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