We are focused on understanding the biology and pathophysiology of infection with the rapid growing multidrug resistant NTM Mycobacterium abscessus as part of the Cystic Fibrosis Trust Strategic Research Centre; an international collaboration with Professor Sir Tom Blundell (Biochemistry, Cambridge), Prof. Julian Parkhill (WT Sanger Institute), Drs Diane Ordway and Mary Jackson (Colorado State University). Together we combine population-level whole genome sequencing, cell biology, biochemistry, animal modelling, structural biology, and computational biology to reveal virulence mechanisms, define host defence factors, and develop novel antibiotics.
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.
Bryant JM*, Grogono DM*,[...], Floto RA.
Science. 2016 : 751-757.
Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study.
Bryant JM et al., Lancet. 2013 May 4;381(9877):1551-60.
Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection.
Renna M et al., J Clin Invest. 2011 Sep;121(9):3554-63.