The Team

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Professor Floto is keen to welcome new ideas and competences in the lab!

Prof. Andres Floto

 

Principal Investigator.

Andres Floto is Professor of Respiratory Biology at the University of Cambridge, a Wellcome Trust Senior Investigator, and Research Director of the Cambridge Centre for Lung Infection at Papworth Hospital, Cambridge.

His research is focused on understanding how immune cells interact with bacteria, how intracellular killing and inflammation are regulated and sometimes subverted during infection, how population-level whole genome sequencing can be used to reveal biology of bacterial infection, and how therapeutic enhancement of cell-autonomous immunity may provide novel strategies to treat multi drug resistant pathogens.

 

Clinically, he specialises in the treatment of patients with Cystic Fibrosis (CF), non-CF bronchiectasis, and infections with Nontuberculous Mycobacteria (NTM). He is co-chair of the British Thoracic Society NTM guidelines committee, the joint US CF Foundation-European CF Society (ECFS) NTM Guidelines Group and the ECFS working group on NTM.

Dr. Anja hagting

 

Lab Manager.
 

After being a postdoc for more than two decades in the cell cycle field I joined the Floto lab in February 2019 for a new role and new research topic. While learning all the ins and outs of innate immunity, I will try to keep the lab running as smoothly as possible. When I’m not in the lab, I enjoy spending time with family and friends, going for hikes and playing badminton.

Karen Brown

 

Research Fellow, NHS.
 

For the past 7 years I have been part of the research team of Professor Floto. Previous to this I was a clinical scientist in molecular haemostasis at Addenbrookes Hospital.
I divide my time between Papworth Hospital in the Cambridge Centre for Lung Infection where I undertake patient related duties, and the MRC LMB where I undertake academic research. I thoroughly enjoy the two very different aspects of my work. The main focus of my research interests is centred around the problematic mycobacterial infection systems which occur within the Cystic Fibrosis patient population.

Louise ellison

 

Research Assistant PhD Student.
 

I am a microbiologist with strong interests in the study of bacterial pathogens and the ways in which they interact and cause disease within their hosts,  as well as the development of drugs and vaccines against infection.

Outside of work, I enjoy keeping active with belly dancing and Bouncefit, and  spending quality time with my family.

Jasper sangen

 

Research Assistant.
 

I am a microbiologist who just moved from the Netherlands to Cambridge with a particular interest in medical microbiology. Understanding the essential pathways and virulence factors involved in pathogen-host interactions is a major interest of mine. Being part of this group is a great opportunity for me to work on my practical skills and knowledge and I look forward to all the techniques that I will learn. Besides this my main interests are doing lots of sports, traveling and cooking.

Judy Younts-Ryan

 

BSc, Project Manager Cystic Fibrosis Innovation Hub, CF Trust.
 

I previously worked as a nurse for over 30+ years in the NHS and the last 15 years within Research managing the Cambridge Centre for Lung Infections Research Team at Royal Papworth Hospital.  I have project managed numerous clinical trials within Bronchiectasis and Cystic Fibrosis.

 

My current role as project manager of the CF Innovation Hub is to oversee the collaboration of world-class researchers throughout the UK and beyond, working towards improving lung health for individuals with CF.  To help create an exceptional CF Research Facility, centred in Cambridge whilst networking with collaborating centres across the UK, delivering transformational treatments for bacterial infections, chronic inflammation and lung repair for people with CF.  We aim to create national networks in key arears to foster and help identify the synergies across the UK in key areas such as stem cells.

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dr. divya arora

 
Post-Doctoral Research Associate.
 

 

 

 

 

Dr. IRIS batalha

 

Post-Doctoral Research Associate, Rosetrees Trust.

I am Postdoctoral Researcher working between the Floto group and Mark Welland group at the Nanoscience Centre of University of Cambridge. I am developing a novel nanoparticle drug delivery system to enable targeted, controlled and sustained release of pharmaceuticals to treat Tuberculosis. I am a Chemist with a PhD in Bioengineering Systems. Previously, I worked within an industrial/academic project funded by MedImmune, which explored the use of bacterial spore molecules for antibody formulation. I enjoy diving in exploratory and outside the box projects, where I can use my skills and creativity. I supervise for several University of Cambridge colleges as I love teaching and exchanging ideas with students. I take every opportunity I can to travel around the world, discover new places and meet new people. I live surrounded with music, cinema and dance. 

dr. Josephine Bryant

 
Post-Doctoral Research Associate, Wellcome Trust.
 

I am a Henry Wellcome postdoctoral fellow working between the Floto group and the Wellcome Trust Sanger Institute. My research uses whole genome sequencing  to understand the evolution of pathogens. During my fellowship I will be focusing on understanding the within host evolution of cystic fibrosis pathogens and how this relates to clinical outcome. 

Dr. Sophie Burbaud

 
Post-Doctoral Research Associate.
 

For a long time now, I have always wished to implicate myself in the fight against infectious diseases. Curious, eager to learn and to solve problems, it appeared obvious to me to direct myself toward the field of Research. 
What better way than to do so in the fast moving and resourceful environment of Cambridge? Just arriving from France, I can also mix my vocation for science with my passion for travelling and discovering new cultures.

 

Dr. sina krokowski

 
Post-Doctoral Research Associate.
 

I’m a microscopist interested in host-pathogen interactions, specifically cell-autonomous immunity against bacteria. I’ve recently completed my PhD in the Mostowy group where I studied the cytoskeleton during bacterial infection. Now in the Floto group, I’m investigating host factors restricting intracellular bacteria and I’m excited to learn techniques beyond microscopy. Outside the lab I love CCC (cooking, climbing and computer games).

dr. Charlotte Passemar

Post-Doctoral Research Associate, MRC-DBT Fellowship.
 

I did my PhD in Toulouse, France, working on the role of Mycobacterium tuberculosis cell wall components in the modulation of innate immune response. I am now pursuing on mycobacterial infections research focusing on the role of autophagy in Mycobacterium tuberculosis clearance. I started this postdoc in Septembre 2015 and I really enjoy my time in this new lab, as well as my new life in Cambridge, even though I am missing the "South of France Sunny days" from time to time!

dr. Chris ruis

Post-Doctoral Research Associate.
 

In my research I use genetic sequences to understand the evolutionary dynamics of pathogens and the factors that influence pathogen transmission and spread. By combining pathogen genome sequences with evolutionary methods, I aim to understand pathogen evolution at all scales, from infections of individual patients through to large outbreaks. I’m currently working to understand when, where and why Mycobacterium abscessusemerged to become a highly prevalent cause of morbidity in patients with Cystic Fibrosis. This work will inform efforts to prevent patients becoming infected in the future. I’m also working to develop new methods to understand evolution of the bacterial pangenome. Historically, I’m a virologist, and maintain an interest in virus evolution and spread, in particular norovirus, the leading cause of gastroenteritis worldwide.

dr. aaron weimann

Post-Doctoral Research Associate.

I am a research associate in pathogen bioinformatics co-supervised by Prof. Floto at the LMB and Prof. Parkhill in the Pathogen Genomics group at the Wellcome Trust Sanger Institute. My postdoc project is on Pseudomonas aeruginosa, which is a prevalent hospital-acquired pathogen and frequently associated with infections in cystic fibrosis patients. I am working on establishing a genomic model of P. aeruginosa by relating high-throughput phenotype data – particularly virulence related phenotypes – and single-cell transcriptome sequencing data with the ultimate goal of gaining a better understanding of pathogenicity using methods from machine learning, genome wide association studies, image processing, etc.. 

Outside of academia I like to sing and I am currently looking for a new choir in Cambridge. The lab is really international and it’s always fun to learn about the various cultural backgrounds represented in our group.

 

dr. Yu zhang

Post-Doctoral Research Associate.

I’m a biophysicist interested in using advanced optical methods such as superresolution imaging, single molecule tracking, FLIM, FRAP, FRET, to study various biologyical system. By combineing  physiological techniques I am interested in understanding the cellular and network in hippocampus, the function of cortical-hippocampal interaction in memory retrieval, cholinergic and dopaminergic modulation at the cellular and network levels and their pathology in CNS disease.  On the other hand, I am developing a new ‘class’ of microscope; one that can simultaneously image protein dynamics, at the level of single molecules, and regulate ion-channel function with electrophysiology tools. Find a fast and reliable protein function monitor tool by correlating single molecule motion states with protein functional status. Design potential therapeutic compounds targeting membrane proteins.I joined the group in 2019 to investigate the function of calcium signalling in epithial cells and macrophages using a cell model of Cystic Fibrosis.

dr. odiri eneje

 

Clinical Fellow, PhD Student

I am an East of England Respiratory and General Medicine trainee. I have an interest in lung infections and its inflammatory response. I have taken time out of clinical training to undertake a period of research. My research focus is investigating novel therapies in modulating inflammation and prevention of chronic lung damage. My hobbies outside of work include hockey, dancing and diving.

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dr. Ieuan Evans

 

Clinical Fellow, PhD Student

I am a trainee in Respiratory/General Medicine in the East of England Deanery with an interest in complex lung infection, bronchiectasis and Cystic Fibrosis. I currently hold the position of Clinical Research Fellow with the Cambridge Centre for Lung Infection based at MRC-LMB & Papworth Hospital. I am analyzing the current available treatment options targeting Mycobacterium abscessus with the aim of developing an optimal treatment regimen. I will additionally aim to assess the mechanisms of antibiotic accumulation within M. abscessus. Alongside this I will also be looking to identify new antimicrobial agents targeting Mycobacterium infections, specifically TB.

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gabrielle budd

PhD Student.

I am a junior doctor with an MBChB and BMedSc(Hons) from Otago University in New Zealand. I have an interest in research and immunology and have spent my honours research year looking at the innate immunity of the small intestine in the context of Crohn's disease. This PhD project will investigate how the genetic variation of human macrophages results in differences in host susceptibility to Mycobacterium tuberculosis. My hobbies include hiking, Roller Derby and Irish dance.

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Santiago caño-muñiz

PhD Student.

I am Santiago Caño-Muñiz PhD student at Floto Lab. Rise and educated in Madrid, I received my degree in Biology by the Universidad Autonoma de Madrid. Recently, I completed an MSc in Molecular Biology and Biotechnology at the Rijksuniversiteit Groningen. I decided to join the group to investigate how the bacteria get into dormant state and became tolerant to antibiotic treatments. When I am not in the lab, you can find me most of the time in one of the many Salsa, Bachata or Latin dance events around the town.

Damian sutcliffe

PhD Student.     

I am leveraging the daily physiological telemetry recordings and longitudinal clinical metadata collected through the UK SmartCareCF study to develop generative graphical models of the processes leading to acute pulmonary exacerbations (APE’s) in people with Cystic Fibrosis to i) gain insight into the pathophysiology of APE's which might subsequently be testable clinically or experimentally, and ii) develop algorithms that might predict the onset of APE's, which could potentially be used clinically to trigger early antibiotic therapy. Prior to this, I recently retired from a 25 year career in Technology in the Financial Services Industry. Outside of studying/working, I enjoy cycling and relaxing with my family.

They started new adventures!

Dr. Daniela Rodriguez-Rincon

Dr. agnes foeglein

Dr. Mark schiebler

Catherine klapholz

Dariya Nikitin

Dr. Isobel everall

vasanthini athithan

dr. lucas boeck

dr. dorothy grogono

Dr. charlotte

maserumule

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