We are interested in defining the critical molecular pathways that restrict intracellular bacterial growth. We are employing both CRISPR-Cas9 based forward genetic screens and candidate gene approaches from population genetic studies to identify key nodal genes and then understand their mechanism of action through cellular and biochemical analysis.
Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion.
Schiebler M, et al., EMBO Mol Med. 2014 Dec 22;7(2):127-39.
Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5.
Floto RA et al., Science. 2006 Oct 20;314(5798):454-8.